Back to Search
Start Over
Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next
- Source :
- Journal of psychopharmacology (Oxford, England), vol 30, iss 11
- Publication Year :
- 2016
-
Abstract
- Our 1992 paper, ‘The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications’, reviewed a series of (then) new and preliminary findings from cross-species studies of prepulse inhibition of the startle reflex, and commented on their implications. At the time that the report was composed, PubMed listed about 40 citations for studies using the search term ‘prepulse inhibition’. In the ensuing 25 years, the field has added about 2700 such reports, reflecting the substantial growth in interest in prepulse inhibition and its utility across a number of different experimental applications. The 30th anniversary of the Journal of Psychopharmacology provides an opportunity to comment briefly on what was described in that 1992 report, how the field has progressed in the subsequent decades, and the paths forward for studies of prepulse inhibition and its use as an operational measure of sensorimotor gating. Among these future paths, we highlight the use of prepulse inhibition as: an endophenotype for genomic studies, and a biomarker for healthy brain circuitry, which may predict sensitivity to psychotherapeutics. Our 1992 report was highly speculative and based on paper-thin empirical data, yet viewed in a certain light, it appears to have contained a basic roadmap for a journey spanning the next 25 years of prepulse inhibition research… and ‘what a long, strange trip it’s been’.
- Subjects :
- Empirical data
Reflex, Startle
Sensorimotor Gating
Medical and Health Sciences
Article
Antipsychotic
03 medical and health sciences
0302 clinical medicine
Reflex
Moro reflex
medicine
Animals
Humans
Pharmacology (medical)
Prepulse inhibition
startle reflex
Psychiatry
Pharmacology
Psychotropic Drugs
prepulse inhibition
Sensory gating
Prepulse Inhibition
Psychology and Cognitive Sciences
Startle
sensorimotor gating
Neurosciences
Brain
Sensory Gating
medicine.disease
030227 psychiatry
schizophrenia
Psychiatry and Mental health
medicine.anatomical_structure
Schizophrenia
Endophenotype
dopamine
Psychology
Neuroscience
030217 neurology & neurosurgery
Biomarkers
Cognitive psychology
Brain circuitry
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of psychopharmacology (Oxford, England), vol 30, iss 11
- Accession number :
- edsair.doi.dedup.....e0fb6d2d8006378dcfc80d9f3116639b