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Are Tanycytes the Missing Link Between Type 2 Diabetes and Alzheimer's Disease?
- Source :
- Molecular neurobiology. 56(2)
- Publication Year :
- 2018
-
Abstract
- Tanycytes are highly specialized bipolar ependymal cells that line the ventrolateral wall and the floor of the third ventricle in the brain and form a blood-cerebrospinal fluid barrier at the level of the median eminence. They play a pivotal role in regulating metabolic networks that control body weight and energy homeostasis. Due to the glucosensing function of tanycytes, they could be considered as a critical player in the pathogenesis of type 2 diabetes. Genetic fate mapping studies have established the role of tanycytes for the newly detected adult hypothalamic neurogenesis with important implications for metabolism as well as pathophysiology of various neurodegenerative diseases. We believe that a comprehensive understanding of the physiological mechanisms underlying their neuroplasticity, glucosensing, and cross talk with endothelial cells will enable us to achieve metabolic homeostasis in type 2 diabetes patients and possibly delay the progression of Alzheimer's disease and hopefully improve cognitive function.
- Subjects :
- 0301 basic medicine
Ependymal Cell
Ependymoglial Cells
Neuroscience (miscellaneous)
Type 2 diabetes
Disease
Energy homeostasis
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Fate mapping
Alzheimer Disease
Neuroplasticity
Medicine
Glucose homeostasis
Animals
Homeostasis
Humans
business.industry
Neurogenesis
Brain
medicine.disease
030104 developmental biology
Neurology
Diabetes Mellitus, Type 2
Blood-Brain Barrier
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15591182
- Volume :
- 56
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecular neurobiology
- Accession number :
- edsair.doi.dedup.....e0bcde00298742e82afd13bec06e9ed5