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2-Year Outcomes of the Eluvia Drug-Eluting Stent for the Treatment of Complex Femoropopliteal Lesions
- Source :
- JACC. Cardiovascular interventions. 14(6)
- Publication Year :
- 2020
-
Abstract
- Objectives The aim of this study was to evaluate the 2-year performance of a polymer-based drug-eluting stent (DES) for the treatment of complex femoropopliteal lesions. Background Despite the promising early outcomes of the Eluvia DES, the long-term safety and efficacy of the device in a real-world scenario remain unclear. Methods Between March 2016 and December 2018, 130 patients (137 lesions) with symptomatic femoropopliteal disease were included in this study. The primary outcome measure of this analysis was primary patency. Secondary patency, freedom from target lesion revascularization, freedom from surgical conversion, and overall mortality and morbidity were additionally analyzed. Results The majority of patients presented with lifestyle-limiting claudication (n = 90 [69%]). The mean lesion length was 194 ± 108 mm, 74% of the lesions (n = 101) were chronic total occlusions, and 72% (n = 99) were calcified. Moderate to severe calcification (Peripheral Arterial Calcium Scoring Scale score 3 or 4) was observed in 48% of the treated vessels (n = 67). At 24 months, the Kaplan-Meier estimate of primary patency was 71%, whereas both the secondary patency rate and freedom from target lesion revascularization were 80%. Overall survival amounted to 85%. Freedom from major amputation was 98%, while freedom from surgical conversion was 89%. Degeneration of the vessel wall was observed in 27 lesions (20%). Conclusions In this study, use of the Eluvia polymer-based DES for the treatment of complex femoropopliteal disease showed promising 2-year results. Nonetheless, a relatively high rate of vessel wall degeneration was observed after DES deployment.
- Subjects :
- medicine.medical_specialty
Paclitaxel
medicine.medical_treatment
030204 cardiovascular system & hematology
Lesion
03 medical and health sciences
Peripheral Arterial Disease
0302 clinical medicine
Aneurysm
medicine
Humans
Popliteal Artery
030212 general & internal medicine
Target lesion revascularization
Vascular Patency
business.industry
Stent
Drug-Eluting Stents
medicine.disease
Surgery
Femoral Artery
Treatment Outcome
Drug-eluting stent
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Claudication
Calcification
Major amputation
Subjects
Details
- ISSN :
- 18767605
- Volume :
- 14
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- JACC. Cardiovascular interventions
- Accession number :
- edsair.doi.dedup.....e0b1113a6f512484ce6b621c1804736b