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Toxicity-Attenuated Glycol Chitosan Adhesive Inspired by Mussel Adhesion Mechanisms
- Source :
- Advanced healthcare materials. 8(14)
- Publication Year :
- 2019
-
Abstract
- Chitosan-catechol, inspired from mussel-adhesive-proteins, is characterized by the formation of an adhesive membrane complex through instant bonding with serum proteins not found in chitosan. Using this intrinsic property, chitosan-catechol is widely applied for hemostatic needles, general hemostatic materials, nanoparticle composites, and 3D printing. Despite its versatility, the practical use of chitosan-catechol in the clinic is limited due to its undesired immune responses. Herein, a catechol-conjugated glycol chitosan is proposed as an alternative hemostatic hydrogel with negligible immune responses enabling the replacement of chitosan-catechol. Comparative cellular toxicity and in vivo skin irritation between chitosan-catechol and glycol chitosan-catechol are evaluated. Their immune responses are also assessed using histological analysis after subcutaneous implantation into mice. The results show that glycol chitosan-catechol significantly attenuates the immune response compared with chitosan-catechol; this finding is likely due to the antibiofouling effect of ethylene glycol groups and the reduced adhesion of immune cells. Finally, the tissue adhesion and hemostatic ability of glycol chitosan-catechol hydrogels reveal that these ethylene glycol groups do not dramatically modify the adhesiveness and hemostatic ability compared with nonglycol chitosan-catechol. This study suggests that glycol chitosan-catechol can be a promising alternative to chitosan-catechol in various biomedical fields such as hemostatic agents.
- Subjects :
- Cell Survival
Biomedical Engineering
Pharmaceutical Science
macromolecular substances
02 engineering and technology
010402 general chemistry
01 natural sciences
Hemostatics
Cell Line
Biomaterials
Chitosan
chemistry.chemical_compound
Mice
Immune system
In vivo
Adhesives
Animals
Skin
Tissue Adhesion
Hemostatic Agent
technology, industry, and agriculture
Adhesiveness
Hydrogels
Adhesion
equipment and supplies
021001 nanoscience & nanotechnology
0104 chemical sciences
Bivalvia
Rats
carbohydrates (lipids)
chemistry
Self-healing hydrogels
Biophysics
bacteria
0210 nano-technology
Ethylene glycol
Subjects
Details
- ISSN :
- 21922659
- Volume :
- 8
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Advanced healthcare materials
- Accession number :
- edsair.doi.dedup.....e0a6e847e08391434f2f4f2945c7ec77