Back to Search
Start Over
KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants
- Source :
- Ke, B; Shen, XD; Zhang, Y; Ji, H; Gao, F; Yue, S; et al.(2013). KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. Journal of Hepatology, 59(6), 1200-1207. doi: 10.1016/j.jhep.2013.07.016. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8n32n8nr, Journal of hepatology, vol 59, iss 6
- Publication Year :
- 2013
- Publisher :
- eScholarship, University of California, 2013.
-
Abstract
- Background & Aims The Keap1-Nrf2 signaling pathway regulates host cell defense responses against oxidative stress and maintains the cellular redox balance. Methods We investigated the function/molecular mechanisms by which Keap1-Nrf2 complex may influence liver ischemia/reperfusion injury (IRI) in a mouse model of hepatic cold storage (20 h at 4 C) followed by orthotopic liver transplantation (OLT). Results The Keap1 hepatocyte-specific knockout (HKO) in the donor liver ameliorated post-transplant IRI, evidenced by improved hepatocellular function and OLT outcomes (Keap1 HKO→Keap1 HKO; 100% survival), as compared with controls (WT→WT; 50% survival; p
- Subjects :
- Male
Neutrophils
OLT
Inbred C57BL
ischemia/reperfusion injury
medicine.disease_cause
environment and public health
PI3K
thioredoxin 1
Oral and gastrointestinal
Mice
Phosphatidylinositol 3-Kinases
TUNEL
Kelch-Like ECH-Associated Protein 1
biology
terminal deoxyribonucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end labeling
Liver Disease
HKO
phosphoinositide 3-kinase
Adaptor Proteins
heme-oxygenase-1
Cytoprotection
ARE
IRI
nuclear factor erythroid 2-related factor 2
Liver
Reperfusion Injury
Public Health and Health Services
sALT
Hypoxia-Inducible Factor 1
Signal transduction
Signal Transduction
Keap1
LDH
serum alanine aminotransferase
NF-E2-Related Factor 2
1.1 Normal biological development and functioning
Chronic Liver Disease and Cirrhosis
Clinical Sciences
HO-1
Cold storage
Liver ischemia/reperfusion injury
hydrogen peroxide
alpha Subunit
Nrf2
Article
orthotopic liver transplantation
Underpinning research
medicine
Animals
Trx1
hepatocyte knockout
Keap1-Nrf2 redox system
anti-oxidant response element
Protein kinase B
PI3K/AKT/mTOR pathway
Adaptor Proteins, Signal Transducing
Transplantation
Liver transplantation
Phosphoinositide 3-kinase
Gastroenterology & Hepatology
Hepatology
Inflammatory and immune system
Macrophages
Signal Transducing
H(2)O(2)
HIF-1
lactate dehydrogenase
Organ Transplantation
medicine.disease
Hypoxia-Inducible Factor 1, alpha Subunit
Molecular biology
hypoxia inducible factor-1
Liver Transplantation
Mice, Inbred C57BL
Cytoskeletal Proteins
HRE
biology.protein
Cancer research
Digestive Diseases
Reperfusion injury
Proto-Oncogene Proteins c-akt
hypoxia response element
Oxidative stress
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Ke, B; Shen, XD; Zhang, Y; Ji, H; Gao, F; Yue, S; et al.(2013). KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. Journal of Hepatology, 59(6), 1200-1207. doi: 10.1016/j.jhep.2013.07.016. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8n32n8nr, Journal of hepatology, vol 59, iss 6
- Accession number :
- edsair.doi.dedup.....e0a55b297076b4d036b5e2ee5fc6f325
- Full Text :
- https://doi.org/10.1016/j.jhep.2013.07.016.