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Bile cast nephropathy: when the kidneys turn yellow
- Source :
- Renal Replacement Therapy, Vol 6, Iss 1, Pp 1-7 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Kidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tubules via several mechanisms. Bile cast nephropathy has characteristic histopathological changes consisting of bilirubin cast deposition in the distal nephron along with tubular epithelial cell injury. Treatment is based on the reversal of liver injury. This review aims to describe bile cast nephropathy in terms of its clinical and morphological features and to shed light on diagnostic techniques. In addition, we present data on management of such nephropathy while reviewing all the reported cases of bile cast nephropathy.
- Subjects :
- Nephrology
medicine.medical_specialty
Pathology
Bilirubin
Urology
030232 urology & nephrology
lcsh:RC870-923
Distal nephron
Cholemic nephropathy
Extracorporeal therapy
Nephropathy
03 medical and health sciences
chemistry.chemical_compound
Liver disease
0302 clinical medicine
Renal injury
Internal medicine
medicine
In patient
Hyperbilirubinemia
Liver injury
Transplantation
business.industry
Bile cast nephropathy
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
chemistry
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 20591381
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Renal Replacement Therapy
- Accession number :
- edsair.doi.dedup.....e0a25b953e185fb3034c338cb3519c23