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Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
- Source :
- Balkan Medical Journal, Vol 34, Iss 1, Pp 28-34 (2017), Balkan Medical Journal
- Publication Year :
- 2016
- Publisher :
- AVES Publishing Co., 2016.
-
Abstract
- WOS: 000396361900004<br />PubMed ID: 28251020<br />Background: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. Aims: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. Study Design: Retrospective, clinical-based multicentric study of 694 patients with pHPT. Methods: Patients from 23 centers and 8 different geographical regions were included. Data related to baseline demographics, clinical, pathologic and treatment characteristics of 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s), histology, as well as the presence of ectopia, presence of dual adenoma, and multiple endocrine neoplasia (MEN)- or familial-related disease. Results: The median age was 54. Asymptomatic patient rate was 25%. The median PTH level was 232 pg/mL and serum total Ca was 11.4 mg/dL. Eighty-seven percent of patients had an adenoma and 90% of these had a single adenoma. Hyperplasia was detected in 79 patients and cancer in 9 patients. The median adenoma size was 16 mm. Significant parameters differing between regions were preoperative symptoms, serum Ca and p levels, and adenoma size. All patients from South-East Anatolia were symptomatic, while the lowest p values were reported from East Anatolia and the largest adenoma size, as well as highest Ca levels, were from Bulgaria. Conclusion: Habitat conditions vary between geographical regions. This affects the clinicopathological features of patients with pHPT.
- Subjects :
- Male
endocrine system diseases
Turkey
IMPACT
lcsh:Medicine
VITAMIN-D STATUS
Gastroenterology
fluids and secretions
0302 clinical medicine
EPIDEMIOLOGY
030212 general & internal medicine
Bulgaria
Multiple endocrine neoplasia
POPULATION
Cerrahi
Aged, 80 and over
Mediterranean Region
Hyperparathyroidism
General Medicine
Middle Aged
Hyperplasia
Hyperparathyroidism, Primary
Brown tumor
medicine.anatomical_structure
Black Sea
Parathyroid Hormone
Original Article
Female
medicine.symptom
clinocopathological features
Adult
medicine.medical_specialty
Adolescent
CARCINOMA
Adenoma
Biochemical Phenomena
030209 endocrinology & metabolism
Asymptomatic
D DEFICIENCY
03 medical and health sciences
Internal medicine
parasitic diseases
medicine
Vitamin D and neurology
Humans
Aged
Retrospective Studies
PARATHYROID ADENOMA WEIGHT
business.industry
lcsh:R
Hospital Distribution Systems
Vitamin D Deficiency
medicine.disease
Calcium
Parathyroid gland
business
Primary hyperparathyroidism
regional differences
Subjects
Details
- ISSN :
- 21463131 and 21463123
- Database :
- OpenAIRE
- Journal :
- Balkan Medical Journal
- Accession number :
- edsair.doi.dedup.....e09b72505cf094dc172e7774f5ccb7f6