Study of glycogen synthesizing and degrading enzymes of guinea pig liver in experimental tuberculosis

Enzymes of the glycogen cycle, namely, UDPG-glycogen transglucosylase, phosphorylase, phosphoglucomutase, and glucose-6-phosphatase, were assayed in the liver of normal and tuberculous guinea pigs. A significant decrease in the activities of the first three enzymes and increase in that of the last one were noted. The decrease in the activity of UDPG-glycogen transglucosylase was of significant magnitude to account for the depletion of the hepatic glycogen in tuberculous guinea pigs.