Back to Search
Start Over
A micro-bead device to explore Plasmodium falciparum-infected, spherocytic or aged red blood cells prone to mechanical retention by spleen endothelial slits
- Source :
- Malaria Journal, Vol 9, Iss Suppl 2, p O10 (2010), Malaria Journal, Malaria Journal, BioMed Central, 2010, 9 (Suppl 2), pp.O10, Malaria Journal, BioMed Central, 2010, 9 (Suppl 2), pp.O10. ⟨10.1186/1475-2875-9-S2-O10⟩, Malaria Journal, 2010, 9 (Suppl 2), pp.O10. ⟨10.1186/1475-2875-9-S2-O10⟩, Europe PubMed Central
- Publication Year :
- 2010
- Publisher :
- BMC, 2010.
-
Abstract
- Experimental tools to identify human red blood cells (RBC) prone to mechanical retention upstream from the spleen venous sinus inter-endothelial slits are currently suboptimal. We designed a micro-bead device mimicking the geometry of the human narrow and short inter-endothelial slits. Upon filtration through a mixture of 5-25 μm diameter micro-beads, Plasmodium falciparum-hosting RBC (Pf-RBC) were retained in a parasite developmental stage-dependent way, the retention rates of a subset of ring-RBC being similar in micro-beads and in isolated-perfused human spleens. We found that this retention might be linked principally to the reduced surface-area-to-volume ratio of Pf-RBC. Interestingly, other rigid RBC, such as heat-treated RBC, and RBC from hereditary spherocytosis patients were also retained in micro-beads without any hemolysis. Micro-beads allow (i) depletion of heterogeneous RBC population from its rigid-RBC subpopulation ii) characteriziation of distinct molecular signatures of rigid versus deformable RBC subpopulations. This simple method portends wide medical applications, such as improving the quality of stored RBC concentrates prior to transfusion.
- Subjects :
- Pathology
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
health care facilities, manpower, and services
education
030231 tropical medicine
Population
Spleen
Hereditary spherocytosis
lcsh:Infectious and parasitic diseases
Blood cell
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
medicine
lcsh:RC109-216
030212 general & internal medicine
health care economics and organizations
education.field_of_study
biology
hemic and immune systems
Plasmodium falciparum
medicine.disease
biology.organism_classification
Molecular biology
Hemolysis
stomatognathic diseases
[ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
medicine.anatomical_structure
Infectious Diseases
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Oral Presentation
Parasitology
circulatory and respiratory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 14752875
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Malaria Journal
- Accession number :
- edsair.doi.dedup.....e09a0b84c7738472ea69b539cc194598