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CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma
- Source :
- Oncoimmunology. 5(6)
- Publication Year :
- 2015
-
Abstract
- Immature myeloid cells such as myeloid-derived suppressor cells (MDSCs) and M2 macrophages play a vital role in the tumor immune escape and tumor progression. Cytotoxic T lymphocyte-associated antigen 4 (CTLA4), as a negative immune checkpoint, is highly expressed in numerous solid tumors. However, precise functions of CTLA4 in head and neck squamous cell carcinoma (HNSCC) have not yet been elucidated. In this study, we demonstrated that the ratio of CD8(+)/CTLA4 can be used as a potential index with a clinical prognostic value for HNSCC. Using immunocompetent transgenic mouse model with spontaneous HNSCC, we directly observed that targeting CTLA4 decreases MDSCs and M2 macrophages and promotes T cell activation in both tumor microenvironment and macro-environment. In all, our study provides direct evidence in vivo and proposes a rationale for CTLA4 inhibition as a future therapeutic strategy in patients with HNSCC.
- Subjects :
- 0301 basic medicine
Tumor microenvironment
medicine.medical_treatment
T cell
Immunology
chemical and pharmacologic phenomena
Immunotherapy
Biology
medicine.disease
Head and neck squamous-cell carcinoma
Immune checkpoint
03 medical and health sciences
stomatognathic diseases
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Oncology
Antigen
Tumor progression
030220 oncology & carcinogenesis
medicine
Immunology and Allergy
Cytotoxic T cell
Original Research
Subjects
Details
- ISSN :
- 21624011
- Volume :
- 5
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Oncoimmunology
- Accession number :
- edsair.doi.dedup.....e094b08c2cbb92636a49677556cdf9c8