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Paper-based sample-to-answer molecular diagnostic platform for point-of-care diagnostics
- Source :
- Biosensors and Bioelectronics. 74:427-439
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Nucleic acid testing (NAT), as a molecular diagnostic technique, including nucleic acid extraction, amplification and detection, plays a fundamental role in medical diagnosis for timely medical treatment. However, current NAT technologies require relatively high-end instrumentation, skilled personnel, and are time-consuming. These drawbacks mean conventional NAT becomes impractical in many resource-limited disease-endemic settings, leading to an urgent need to develop a fast and portable NAT diagnostic tool. Paper-based devices are typically robust, cost-effective and user-friendly, holding a great potential for NAT at the point of care. In view of the escalating demand for the low cost diagnostic devices, we highlight the beneficial use of paper as a platform for NAT, the current state of its development, and the existing challenges preventing its widespread use. We suggest a strategy involving integrating all three steps of NAT into one single paper-based sample-to-answer diagnostic device for rapid medical diagnostics in the near future.
- Subjects :
- Paper
endocrine system
Computer science
Point-of-care testing
Biomedical Engineering
Biophysics
Nanotechnology
Sample (statistics)
Specimen Handling
Electrochemistry
Instrumentation (computer programming)
Medical diagnosis
Oligonucleotide Array Sequence Analysis
Point of care
Medical treatment
Sequence Analysis, RNA
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS
fungi
Equipment Design
Sequence Analysis, DNA
General Medicine
Paper based
Equipment Failure Analysis
body regions
Molecular Diagnostic Techniques
Risk analysis (engineering)
Point-of-Care Testing
Nat
Biotechnology
Subjects
Details
- ISSN :
- 09565663
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Biosensors and Bioelectronics
- Accession number :
- edsair.doi.dedup.....e081fc2a107646a7a79a7659eb3a5bac