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Cognitive changes and quality of life in neurocysticercosis: A longitudinal study
- Source :
- PLoS Neglected Tropical Diseases, Vol 6, Iss 1, p e1493 (2012), PLoS Neglected Tropical Diseases
- Publication Year :
- 2012
- Publisher :
- Public Library of Science, 2012.
-
Abstract
- Background Few studies have focused on the cognitive morbidity of neurocysticercosis (NCC), one of the most common parasitic infections of the central nervous system. We longitudinally assessed the cognitive status and quality of life (QoL) of patients with incident symptomatic NCC cases and matched controls. Methodology/Principal Findings The setting of the study was the Sabogal Hospital and Cysticercosis Unit, Department of Transmissible Diseases, National Institute of Neurological Sciences, Lima, Peru. The design was a longitudinal study of new onset NCC cases and controls. Participants included a total of 14 patients with recently diagnosed NCC along with 14 healthy neighborhood controls and 7 recently diagnosed epilepsy controls. A standardized neuropsychological battery was performed at baseline and at 6 months on NCC cases and controls. A brain MRI was performed in patients with NCC at baseline and 6 months. Neuropsychological results were compared between NCC cases and controls at both time points. At baseline, patients with NCC had lower scores on attention tasks (p<br />Author Summary Neurocysticercosis (NCC) is one of the most common parasitic infections of the central nervous system. Cognitive changes have been frequently reported with this disease but have not been well studied. Our study team recruited a group of new onset NCC cases and a matched set of healthy neighborhood controls and new onset epilepsy controls in Lima, Peru for this study. A neuropsychological battery was administered at baseline and at 6 months to all groups. Brain MRI studies were also obtained on NCC cases at baseline and at 6 months. Newly diagnosed patients with NCC had mild cognitive deficits and more marked decreases in quality of life at baseline compared with controls. Improvements were found in both cognitive status and quality of life in patients with NCC after treatment. This study is the first to assess cognitive status and quality of life longitudinally in patients with NCC and provides new data on an important clinical morbidity outcome.
- Subjects :
- Male
focal epilepsy
Longitudinal study
Pediatrics
Neurocysticercosis
anticonvulsive agent
recall
Neuropsychological Tests
Global Health
mental function
Epilepsy
0302 clinical medicine
Quality of life
problem solving
cognitive defect
Cognitive Changes
Peru
Longitudinal Studies
nuclear magnetic resonance imaging
generalized epilepsy
clinical article
learning
lcsh:Public aspects of medicine
phenytoin
Brain
Cognition
3. Good health
Infectious Diseases
Neurology
carbamazepine
embryonic structures
Medicine
Female
radiography
purl.org/pe-repo/ocde/ford#3.03.06 [https]
Research Article
Adult
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
brain
030231 tropical medicine
albendazole
Cognitive neuroscience
antiparasitic agent
03 medical and health sciences
valproic acid
parasitic diseases
medicine
Humans
follow up
Psychiatry
clonazepam
alertness
psychological aspect
business.industry
urogenital system
Public Health, Environmental and Occupational Health
Case-control study
lcsh:RA1-1270
medicine.disease
social status
attention
Radiography
Short Form 36
affect
Case-Control Studies
Quality of Life
psychomotor performance
business
Cognition Disorders
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases, Vol 6, Iss 1, p e1493 (2012), PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....e078f5d689163c227ff4ad9f3f32df66