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Targeting Parallel Topology of G-Quadruplex Structures by Indole- Fused Quindoline Scaffolds

Authors :
Satendra Kumar
Sushree Prangya Priyadarshinee Pany
Sruthi Sudhakar
Sushma B. Singh
Chaitra S. Todankar
P. I. Pradeepkumar
Source :
Biochemistry. 61(22)
Publication Year :
2022

Abstract

Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has emerged as an effective approach to develop anticancer drugs. Herein, we report the synthesis of three indole-fused quindoline derivatives with varying lengths of side chains (

Details

ISSN :
15204995
Volume :
61
Issue :
22
Database :
OpenAIRE
Journal :
Biochemistry
Accession number :
edsair.doi.dedup.....e071d8965b6cb577e0c38dbf7394e24a