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Novel bio-genetic predictors of response to biologic treatment in inflammatory bowel diseases
- Source :
- Current Opinion in Pharmacology. 55:132-140
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Despite the evolving therapeutic armamentarium, the treatment of IBD patients remains challenging and many patients fail to respond to biologic agents. With the limited yield of clinical factors to predict the outcome of biologic treatments, studies have focused on identifying genetic alterations and circulating or tissue biomarkers to identify patients who are likely to respond to therapy. In this review, we examine the current knowledge and status of genetic, expression biomarkers, and microbiome predictors. The search for genetic predictors has yielded many genetic loci variants, but few were reproducible. Expression studies of putative biomarkers show promising results, especially with TREM1, oncostatin M and TNF biomarkers, but confirmatory studies are warranted. Finally, the microbiome is emerging as an important player with specific taxa and functional pathways differentially abundant and enriched in responders versus non-responders to certain biologics. Integrating different factors into a robust predictive model, which is both reproducible, accurate and affordable, remains the main challenge before these individualized strategies can reach clinical use.
- Subjects :
- 0301 basic medicine
Pharmacology
Biological Products
Genome, Human
business.industry
Inflammatory Bowel Diseases
Biologic treatment
Bioinformatics
030226 pharmacology & pharmacy
Biologic Agents
03 medical and health sciences
Treatment Outcome
030104 developmental biology
0302 clinical medicine
Drug Discovery
Tissue biomarkers
Humans
Medicine
Microbiome
business
Biomarkers
Subjects
Details
- ISSN :
- 14714892
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Pharmacology
- Accession number :
- edsair.doi.dedup.....e06f0bae19aec36f594260bfb189a7a0