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Author Correction: The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells

Authors :
A-Ri Shin
Wook Kim
Heejin Lee
Eun Kyung Lee
Hyosun Tak
Hoin Kang
Woo Keun Song
Chongtae Kim
Yun Hyun Huh
Hyun-Il Cho
Eunbyul Ji
Sojin Ahn
Jun Gi Rho
Source :
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021), Scientific Reports
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.

Details

Language :
English
ISSN :
20452322
Volume :
11
Issue :
1
Database :
OpenAIRE
Journal :
Scientific Reports
Accession number :
edsair.doi.dedup.....e0639c3c395eccf90844874ec6721334