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Identification of an aging-related spherical inclusion in the human brain

Identification of an aging-related spherical inclusion in the human brain

Authors :
Takefumi Yuzuriha
Tsunehiko Ono
Masahiro Shono
Takemi Kimura
Junichi Takamatsu
Toshinori Kitamura
Shoichi Katsuragi
Taihei Miyakawa
Noboru Fujise
Source :
Pathology International. 52:636-642
Publication Year :
2002
Publisher :
Wiley, 2002.

Abstract

Inclusions, such as corpora amylacea, axonal spheroids and ubiquitin-positive granular structures, are present in aged brains. We found a phosphorylated tau-positive inclusion in brain tissues obtained from 13 non-demented subjects and five patients with Alzheimer's disease. This inclusion was spherical and 3-20 microm in size. It was most frequently detected in the hippocampal CA1 region and in the prosubiculum but was not present in the white matter. The density of this inclusion increased significantly with aging and decreased after the occurrence of neurofibrillary tangles. The presence of the inclusion was confirmed using immunoelectron microscopy. These findings show a possibility that the inclusion is a novel aging-related structure in the human brain.

Details

ISSN :
14401827 and 13205463
Volume :
52
Database :
OpenAIRE
Journal :
Pathology International
Accession number :
edsair.doi.dedup.....e05ed270f16d1d995e0f8159fdae43df
Full Text :
https://doi.org/10.1046/j.1440-1827.2002.01402.x