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Identification of an aging-related spherical inclusion in the human brain
Identification of an aging-related spherical inclusion in the human brain
- Source :
- Pathology International. 52:636-642
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- Inclusions, such as corpora amylacea, axonal spheroids and ubiquitin-positive granular structures, are present in aged brains. We found a phosphorylated tau-positive inclusion in brain tissues obtained from 13 non-demented subjects and five patients with Alzheimer's disease. This inclusion was spherical and 3-20 microm in size. It was most frequently detected in the hippocampal CA1 region and in the prosubiculum but was not present in the white matter. The density of this inclusion increased significantly with aging and decreased after the occurrence of neurofibrillary tangles. The presence of the inclusion was confirmed using immunoelectron microscopy. These findings show a possibility that the inclusion is a novel aging-related structure in the human brain.
- Subjects :
- Adult
Male
Phosphopeptides
Aging
Pathology
medicine.medical_specialty
Immunoelectron microscopy
tau Proteins
Hippocampal formation
Pathology and Forensic Medicine
Immunoenzyme Techniques
White matter
Alzheimer Disease
medicine
Humans
Microscopy, Immunoelectron
Aged
Aged, 80 and over
Inclusion Bodies
Axonal spheroids
Chemistry
Brain
Neurofibrillary tangle
General Medicine
Human brain
Middle Aged
medicine.disease
medicine.anatomical_structure
Female
Inclusion (mineral)
Corpora amylacea
Subjects
Details
- ISSN :
- 14401827 and 13205463
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Pathology International
- Accession number :
- edsair.doi.dedup.....e05ed270f16d1d995e0f8159fdae43df
- Full Text :
- https://doi.org/10.1046/j.1440-1827.2002.01402.x