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Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature
- Source :
- Brain Sciences, Brain Sciences, Vol 11, Iss 276, p 276 (2021)
- Publication Year :
- 2020
-
Abstract
- Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points.
- Subjects :
- illness trajectory
Molecular evidence
Review
neuroprogression
illness outcome
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
Neuroimaging
medicine
Bipolar disorder
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
bipolar disorder
Illness trajectory
business.industry
General Neuroscience
Neuropsychology
Retrospective cohort study
Small sample
medicine.disease
030227 psychiatry
Illness course
Illness outcome
Neuroprogression
illness course
business
Psychosocial
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- ISSN :
- 20763425
- Volume :
- 11
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Brain sciences
- Accession number :
- edsair.doi.dedup.....e05b7e0a32dd177848daa92b16386598