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The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease

Authors :
Yamile Bocanegra
Justin S. Sanchez
Rebecca E. Amariglio
Edmarie Guzmán-Vélez
Dorene M. Rentz
Clara Vila-Castelar
Ana Baena
Nathalia Muñoz
Yakeel T. Quiroz
Eric M. Reiman
Kathryn V. Papp
Keith A. Johnson
Reisa A. Sperling
Francisco Lopera
Source :
Alzheimer's Research & Therapy, Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)
Publication Year :
2020
Publisher :
BioMed Central, 2020.

Abstract

Background To determine whether performance on the Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) can differentiate between cognitively intact carriers of an autosomal dominant Alzheimer’s disease mutation (E280A) in Presenilin-1, who are genetically determined to develop early-onset dementia, from matched non-carriers. We also sought to examine whether LAS-FNAME performance is associated with amyloid-β and regional tau burden in mutation carriers. Methods A total of 35 cognitively intact mutation carriers (age range 26–41), 19 symptomatic carriers, and 48 matched non-carriers (age range 27–44) completed a neuropsychological assessment including the LAS-FNAME. A subset of participants (31 carriers [12 symptomatic] and 35 non-carriers) traveled from Colombia to Boston to undergo positron emission tomography (PET) using Pittsburgh compound B to measure mean cortical amyloid-β and flortaucipir for regional tau. ANOVA analyses and Spearman correlations were used to examine group differences and relationships among LAS-FNAME performance and amyloid-β and tau accumulation. Results Compared to non-carriers, cognitively intact mutation carriers had lower scores on the LAS-FNAME Total Scores (p = .040). Across all carriers (including symptomatic carriers), higher levels of amyloid-β (r = − .436, p = .018) and regional tau in the entorhinal (r = − .394, p = .031) and inferior temporal cortex (r = − .563, p = .001) were associated with lower LAS-FNAME Total Scores. Conclusions Performance on the LAS-FNAME differentiated between cognitively intact mutation carriers from non-carriers and was associated with greater amyloid and tau burden when examining all carriers. Findings suggest that the LAS-FNAME is sensitive to early clinical and pathological changes and can potentially help track disease progression in Spanish-speaking individuals.

Details

Language :
English
ISSN :
17589193
Volume :
12
Database :
OpenAIRE
Journal :
Alzheimer's Research & Therapy
Accession number :
edsair.doi.dedup.....e04ccc9d953109b80572f4f60660a30e