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Multi-targeted therapy of cancer by omega-3 fatty acids-an update
- Source :
- Cancer Letters. 526:193-204
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Low in dietary ω3 polyunsaturated fatty acid (PUFA) consumption has been associated with increased incidence of cancers. Many basic and clinical studies have been conducted over the last several decades. We previously reviewed multi-targeted therapy of cancer by omega-3 fatty acids in 2008, and since hundreds of new clinical trials are being conducted to validate the effectiveness of ω3 PUFA in cancer therapy. Because of the availability of such large amount of clinical trial data, in this update we summarize clinical data, sort out trials that show promising results, and discuss potential mechanism(s) responsible for the clinical outcomes. It appears that ω3 PUFA mainly affects cancer-associated symptoms, namely cachexia, inflammation, neuropathy, post operative complications and quality of life. Mechanisms responsible for these effects are possible regulation of skeletal muscle protein turnover, inflammatory response and neuron cell survive by ω3 PUFA.
- Subjects :
- chemistry.chemical_classification
Cancer Research
business.industry
medicine.medical_treatment
Protein turnover
Cancer
Inflammation
medicine.disease
Bioinformatics
Targeted therapy
Cachexia
Clinical trial
Oncology
Quality of life
chemistry
Neoplasms
Fatty Acids, Omega-3
Quality of Life
Humans
Medicine
medicine.symptom
business
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 526
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....e03387dab85f4f738e92099b64c2936e