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Microsatellite instability analysis of sinonasal carcinomas
- Source :
- Otolaryngology–Head and Neck Surgery. 140:55-60
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Objectives Intestinal-type sinonasal adenocarcinoma (ITAC) and squamous cell carcinoma of the nasal cavity (SCCNC) are histopathologically but not etiologically similar to colorectal adenocarcinoma or to laryngeal squamous cell carcinoma, respectively. Microsatellite instability (MSI) is involved in both tumors. The aim of this study was to investigate a possible role for MSI in the pathogenesis of two types of nasal carcinoma. Material and Methods DNA obtained from frozen tumor samples of 41 ITACs and 24 SCCNCs was analyzed for shifts in five mononucleotide microsatellite loci by multiplex PCR. Results The allelic patterns of one ITAC (2%) and five SCCNCs (21%) revealed an allelic shift for at least one of the five loci, indicating microsatellite instability. Conclusion MSI may be involved in squamous cell carcinoma, but not in adenocarcinoma of the nasal cavities.
- Subjects :
- Male
Nasal cavity
Pathology
medicine.medical_specialty
Nose Neoplasms
Adenocarcinoma
Biology
Polymerase Chain Reaction
Multiplex polymerase chain reaction
medicine
Carcinoma
Humans
Allele
Aged
Aged, 80 and over
Microsatellite instability
Middle Aged
medicine.disease
medicine.anatomical_structure
Otorhinolaryngology
Carcinoma, Squamous Cell
Microsatellite
Female
Microsatellite Instability
Surgery
Microsatellite Instability Analysis
Subjects
Details
- ISSN :
- 10976817 and 01945998
- Volume :
- 140
- Database :
- OpenAIRE
- Journal :
- Otolaryngology–Head and Neck Surgery
- Accession number :
- edsair.doi.dedup.....e02deea6fcd46c04675d78c2b9b5be94