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New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients
- Source :
- Blood. 110:4385-4395
- Publication Year :
- 2007
- Publisher :
- American Society of Hematology, 2007.
-
Abstract
- We have generated a large, unique database that includes morphologic, clinical, cytogenetic, and follow-up data from 2124 patients with myelodysplastic syndromes (MDSs) at 4 institutions in Austria and 4 in Germany. Cytogenetic analyses were successfully performed in 2072 (97.6%) patients, revealing clonal abnormalities in 1084 (52.3%) patients. Numeric and structural chromosomal abnormalities were documented for each patient and subdivided further according to the number of additional abnormalities. Thus, 684 different cytogenetic categories were identified. The impact of the karyotype on the natural course of the disease was studied in 1286 patients treated with supportive care only. Median survival was 53.4 months for patients with normal karyotypes (n = 612) and 8.7 months for those with complex anomalies (n = 166). A total of 13 rare abnormalities were identified with good (+1/+1q, t(1q), t(7q), del(9q), del(12p), chromosome 15 anomalies, t(17q), monosomy 21, trisomy 21, and −X), intermediate (del(11q), chromosome 19 anomalies), or poor (t(5q)) prognostic impact, respectively. The prognostic relevance of additional abnormalities varied considerably depending on the chromosomes affected. For all World Health Organization (WHO) and French-American-British (FAB) classification system subtypes, the karyotype provided additional prognostic information. Our analyses offer new insights into the prognostic significance of rare chromosomal abnormalities and specific karyotypic combinations in MDS.
- Subjects :
- Oncology
medicine.medical_specialty
Monosomy
Pathology
Databases, Factual
Immunology
Biology
Biochemistry
03 medical and health sciences
Chromosome 15
0302 clinical medicine
Germany
Internal medicine
medicine
Humans
Chromosome Aberrations
De novo Myelodysplastic Syndrome
Karyotype
Cell Biology
Hematology
Classification
Prognosis
medicine.disease
3. Good health
Survival Rate
International Prognostic Scoring System
Austria
Karyotyping
Myelodysplastic Syndromes
030220 oncology & carcinogenesis
Cytogenetic Analysis
Chromosome abnormality
Chromosome 21
Trisomy
030215 immunology
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....e026cc82d2711ca0be7e4238711e3e92