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Rapid detoxification of benzodiazepine or Z-drugs dependence using acetylcholinesterase inhibitors
- Source :
- Medical hypotheses. 83(1)
- Publication Year :
- 2013
-
Abstract
- Dependence on benzodiazepines (BZDs) or Z-drugs (zolpidem, zopicline and zaleplon) is a common clinical phenomenon. Traditional detoxification of BZDs dependence includes tapering used dose gradually and using equivalent doses of long-acting BZDs as substitutes. This kind of regimen tends to take a long time (up to 4weeks) and may require hospitalization. Acetylcholinesterase inhibitors have been shown to reverse BZDs induced sedation. We propose that oral form acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) also posses the effect of inhibiting GABA receptors, and act as indirect antagonist, to be applied in the rapid detoxification treatment of BZDs and Z-drug dependence.
- Subjects :
- Rivastigmine
Benzodiazepine
Zolpidem
medicine.drug_class
Substance-Related Disorders
General Medicine
Pharmacology
Middle Aged
Acetylcholinesterase
chemistry.chemical_compound
Zaleplon
Benzodiazepines
chemistry
Detoxification
medicine
Galantamine
Humans
Female
Cholinesterase Inhibitors
Donepezil
medicine.drug
Subjects
Details
- ISSN :
- 15322777
- Volume :
- 83
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Medical hypotheses
- Accession number :
- edsair.doi.dedup.....e01ff9646926188508e5c36f6f8dec3c