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Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS)
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 68, iss 11
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Patient management is not based on a single decision. Rather, it is dynamic: based on a sequence of decisions, with therapeutic adjustments made over time. Adjustments are personalized: tailored to individual patients as new information becomes available. However, strategies allowing for such adjustments are infrequently studied. Traditional antibiotic trials are often nonpragmatic, comparing drugs for definitive therapy when drug susceptibilities are known. COMparing Personalized Antibiotic StrategieS (COMPASS) is a trial design that compares strategies consistent with clinical practice. Strategies are decision rules that guide empiric and definitive therapy decisions. Sequential, multiple-assignment, randomized (SMART) COMPASS allows evaluation when there are multiple, definitive therapy options. SMART COMPASS is pragmatic, mirroring clinical, antibiotic-treatment decision-making and addressing the most relevant issue for treating patients: identification of the patient-management strategy that optimizes the ultimate patient outcomes. SMART COMPASS is valuable in the setting of antibiotic resistance, when therapeutic adjustments may be necessary due to resistance.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
pragmatic trial
medicine.medical_specialty
Definitive Therapy
030106 microbiology
Clinical Decision-Making
Clinical Trials and Supportive Activities
Invited Articles
Medical and Health Sciences
Microbiology
law.invention
7.3 Management and decision making
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Clinical Research
Compass
Medicine
Humans
Medical physics
030212 general & internal medicine
Precision Medicine
sequential randomization
Randomized Controlled Trials as Topic
business.industry
Disease Management
Evaluation of treatments and therapeutic interventions
Decision rule
Biological Sciences
Patient management
Anti-Bacterial Agents
Clinical Practice
Identification (information)
Infectious Diseases
Good Health and Well Being
Research Design
5.1 Pharmaceuticals
6.1 Pharmaceuticals
Patient Safety
Antimicrobial Resistance
Management of diseases and conditions
Development of treatments and therapeutic interventions
business
strategy
Mirroring
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 68, iss 11
- Accession number :
- edsair.doi.dedup.....e0185928a2783cae6cbf09936469a52e