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5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase
- Source :
- Chemical communications (Cambridge, England). 53(99)
- Publication Year :
- 2017
-
Abstract
- DNA templates containing 5-hydroxymethyluracil or 5-hydroxymethylcytosine were used in an in vitro transcription assay with RNA polymerase from Escherichia coli. A strong enhancement of transcription was observed from DNA containing the Pveg promoter whereas a decrease was observed from DNA containing the rrnB P1 promoter, suggesting that they may act as epigenetic marks.
- Subjects :
- 0301 basic medicine
Transcription, Genetic
Response element
RNA polymerase II
Catalysis
Epigenesis, Genetic
Pentoxyl
03 medical and health sciences
chemistry.chemical_compound
Cytosine
Transcription (biology)
RNA polymerase
Materials Chemistry
Escherichia coli
Polymerase
biology
General transcription factor
Chemistry
Metals and Alloys
Promoter
General Chemistry
DNA-Directed RNA Polymerases
Molecular biology
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
030104 developmental biology
Biochemistry
Ceramics and Composites
biology.protein
Transcription factor II D
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 53
- Issue :
- 99
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....e017a82ebbd84168000851a5e01d4fe2