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Correlation between retinal vascular parameters and cystatin C in patients with type 2 diabetes
- Source :
- Acta Diabetologica. 58:1395-1401
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- To investigate the relationship between retinal vascular parameters and cystatin C in patients with type 2 diabetes in northwestern China. This was a cross-sectional study of 1689 patients with type 2 diabetes. A validated fully automated computer program was used to extract retinal vascular parameters from the entire vascular tree. Multiple logistic regression analyses were conducted to investigate the relationship between these vascular measurements and cystatin C. For retinal vascular geometrical measurements, smaller arteriolar fractal dimension was related to high cystatin C after adjusting for multiple variables (odds ratio [OR] 0.149, 95% CI 0.042–0.532). For retinal vascular caliber measurements, narrower central and middle arteriolar calibers were related to high cystatin C after adjusting for multiple variables (central: OR 0.922, 95% CI 0.886–0.960; middle: OR 0.940, 95% CI 0.901–0.981). Wider central, middle and peripheral venular calibers were associated with high cystatin C after adjusting for multiple variables (central: OR 1.058, 95% CI 1.003–1.117; middle: OR 1.094, 95% CI 1.040–1.150; peripheral: OR 1.075, 95% CI 1.023–1.130). Multiple retinal vascular geometrical and caliber measurements are associated with cystatin C in type 2 diabetic patients. Further studies are needed to explore whether these retinal vascular changes can predict the incidence and progress of diabetic nephropathy.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
Logistic regression
Diabetic nephropathy
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Cystatin C
Diabetic Retinopathy
biology
business.industry
Retinal Vessels
Retinal
General Medicine
Odds ratio
medicine.disease
Cross-Sectional Studies
Diabetes Mellitus, Type 2
chemistry
Cardiology
biology.protein
Cystatin
business
Subjects
Details
- ISSN :
- 14325233 and 09405429
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica
- Accession number :
- edsair.doi.dedup.....dff8b5b78a2f0c3f5a5a2958b4f62d8b