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Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk
- Source :
- BMC Cancer, BMC Cancer, Vol 8, Iss 1, p 112 (2008)
- Publisher :
- Springer Nature
-
Abstract
- Backgroud Patients with chronic inflammatory bowel disease (IBD) are at an increased risk of colorectal cancer (CRC) and it is estimated that one in six persons diagnosed with IBD will develop CRC. This fact suggests that genetic variations in inflammatory response genes may act as CRC disease risk modifiers. Methods In order to test this hypothesis we investigated a series of polymorphisms in 6 genes (NOD2, DLG5, OCTN1, OCTN2, IL4, TNFα) associated with the inflammatory response on a group of 607 consecutive newly diagnosed colorectal cancer patients and compared the results to controls (350 consecutive newborns and 607 age, sex and geographically matched controls). Results Of the six genes only one polymorphism in TNFα(-1031T/T) showed any tendency to be associated with disease risk (64.9% for controls and 71.4% for CRC) which we further characterized on a larger cohort of CRC patients and found a more profound relationship between the TNFα -1031T/T genotype and disease (64.5% for controls vs 74.7% for CRC cases above 70 yrs). Then, we investigated this result and identified a suggestive tendency, linking the TNFα -1031T/T genotype and a previously identified change in the CARD15/NOD2 gene (OR = 1.87; p = 0,02 for CRC cases above 60 yrs). Conclusion The association of polymorphisms in genes involved in the inflammatory response and CRC onset suggest that there are genetic changes capable of influencing disease risk in older persons.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Cancer Research
Organic Cation Transport Proteins
Colorectal cancer
Nod2 Signaling Adaptor Protein
Disease
lcsh:RC254-282
Inflammatory bowel disease
Risk Factors
Polymorphism (computer science)
NOD2
Internal medicine
Genotype
medicine
Genetics
Humans
Genetic Predisposition to Disease
Genetic Testing
Solute Carrier Family 22 Member 5
Aged
Genetic testing
Aged, 80 and over
Polymorphism, Genetic
Symporters
medicine.diagnostic_test
Tumor Necrosis Factor-alpha
business.industry
Tumor Suppressor Proteins
Age Factors
Case-control study
Membrane Proteins
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Inflammatory Bowel Diseases
medicine.disease
digestive system diseases
Case-Control Studies
Immunology
Female
Interleukin-4
Colorectal Neoplasms
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....dff09da4199f0ef3fd9c47a520d7bcfe
- Full Text :
- https://doi.org/10.1186/1471-2407-8-112