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The chromosome 9 ALS and FTD locus is probably derived from a single founder

Authors :: John Hardy
Javier Simón-Sánchez
Terhi Peuralinna
Aleksey Shatunov
Hannu Laaksovirta
Gabriele Mora
Kin Y. Mok
Pentti J. Tienari
Adrian James Waite
Jennifer C. Schymick
Pamela Sara Rollinson
Karen E. Morrison
Richard W. Orrell
John C. van Swieten
Stuart Pickering-Brown
Mariely DeJesus-Hernandez
Adam L. Boxer
Rosa Rademakers
Bradley F. Boeve
Adriano Chiò
Peter Heutink
Nigel Williams
Liisa Myllykangas
Mike A. Nalls
Pamela J. Shaw
Ammar Al-Chalabi
Bryan J. Traynor
Ian R. A. Mackenzie
Gabriella Restagno
Huw R. Morris
Human genetics
NCA - Neurodegeneration
Neurology
Erasmus MC other
Source :: Neurobiology of Aging, King's College London, Neurobiology of Aging; Vol 33, Neurobiology of Aging, 33(1), 209.e3-209.e8. Elsevier Inc., Mok, K, Traynor, B J, Schymick, J, Tienari, P J, Laaksovirta, H, Peuralinna, T, Myllykangas, L, Chio, A, Shatunov, A, Boeve, B F, Boxer, A L, Jesus-Hernandez, M, Mackenzie, I R, Waite, A, Williams, N, Morris, H R, Simon-Sanchez, J, van Swieten, J C, Heutink, P, Restagno, G, Mora, G, Morrison, K E, Shaw, P J, Rollinson, P S, Al-Chalabi, A, Rademakers, R, Pickering-Brown, S, Orrell, R W, Nalls, M A & Hardy, J 2012, ' The chromosome 9 ALS and FTD locus is probably derived from a single founder ', Neurobiology of Aging, vol. 33, no. 1, pp. 209.e3-209.e8 . https://doi.org/10.1016/j.neurobiolaging.2011.08.005, Neurobiology of aging, Neurobiology of Aging, 33(1). Elsevier Inc.
Publisher :: Elsevier Inc. Published by Elsevier Inc.
Abstract: We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. (C) 2012 Elsevier Inc. All rights reserved.