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Gastric Cancer Heterogeneity and Clinical Outcomes
- Source :
- Technology in Cancer Research & Treatment, Vol 19 (2020), Technology in Cancer Research & Treatment
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- Gastric adenocarcinoma is a highly aggressive disease with poor overall survival. The aggressive nature of this disease is in part due to the high intra and inter tumoral heterogeneity and also due to the late diagnosis at presentation. Once progression occurs, treatment is more difficult due to the adaptation of tumors, which acquires resistance to commonly used chemotherapeutics. In this report, using publicly available data sets and pathway analysis, we highlight the vast heterogeneity of gastric cancer by investigating genes found to be significantly perturbed. We found several upregulated genes in the diffuse gastric cancer subtypes share similarity to gastric cancer as a whole which can be explained by the increase in this subtype of gastric cancer throughout the world. We report significant downregulation of genes that are underrepresented within the literature, such as ADH7, GCNT2, and LIF1, while other genes have not been explored within gastric cancer to the best of our knowledge such as METTL7A, MAL, CWD43, and SLC2A12. We identified gender to be another heterogeneous component of this disease and suggested targeted treatment strategies specific to this heterogeneity. In this study, we provide an in-depth exploration of the molecular landscape of gastric cancer in order to shed light onto novel areas of gastric cancer research and explore potential new therapeutic targets.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Review
Aggressive disease
Disease
lcsh:RC254-282
Genetic Heterogeneity
03 medical and health sciences
Gastric adenocarcinoma
Sex Factors
0302 clinical medicine
Downregulation and upregulation
Stomach Neoplasms
Internal medicine
Databases, Genetic
microRNA
Biomarkers, Tumor
medicine
Humans
Gene Regulatory Networks
differential gene expression
030304 developmental biology
0303 health sciences
business.industry
gastric cancer
Gene Expression Profiling
oncomine
Computational Biology
Cancer
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Pathway analysis
medicine.disease
Gene Expression Regulation, Neoplastic
classification
Late diagnosis
030220 oncology & carcinogenesis
Female
Neoplasm Grading
Transcriptome
business
Subjects
Details
- ISSN :
- 15330338 and 15330346
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Technology in Cancer Research & Treatment
- Accession number :
- edsair.doi.dedup.....dfcc058971cb8e7ca6e598733b31a3a9