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Head and neck cancer: the role of anti-EGFR agents in the era of immunotherapy
- Source :
- Therapeutic Advances in Medical Oncology, Therapeutic Advances in Medical Oncology, Vol 13 (2021)
- Publication Year :
- 2021
-
Abstract
- Head and neck cancers (HNC) represent the seventh most frequent cancer worldwide, with squamous cell carcinomas as the most frequent histologic subtype. Standard treatment for early stage diseases is represented by single modality surgery or radiotherapy, whereas in the locally advanced and recurrent or metastatic settings a more aggressive multi-modal approach is needed with locoregional intervention and/or systemic therapies. Epidermal Growth Factor Receptor (EGFR) plays an important role in HNC biology and has been studied extensively in preclinical and clinical settings. In this scenario, anti-EGFR targeted agent cetuximab, introduced in clinical practice a decade ago, represents the only approved targeted therapy to date, while the development of immune-checkpoint inhibitors has recently changed the available treatment options. In this review, we focus on the current role of anti-EGFR therapies in HNCs, underlying available clinical data and mechanisms of resistance, and highlight future perspectives regarding their role in the era of immunotherapy.
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
EGFR
Review
lcsh:RC254-282
HNSCC
Targeted therapy
Internal medicine
cetuximab
medicine
Epidermal growth factor receptor
Cetuximab
biology
business.industry
Standard treatment
Head and neck cancer
Cancer
Immunotherapy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Radiation therapy
HNC
biology.protein
immunotherapy
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Therapeutic Advances in Medical Oncology, Therapeutic Advances in Medical Oncology, Vol 13 (2021)
- Accession number :
- edsair.doi.dedup.....dfca2c71f584f9b29b734d13d15364d5