Back to Search
Start Over
Lower Skin Cancer Risk in Women with Higher Body Mass Index: The Women's Health Initiative Observational Study
- Source :
- Cancer Epidemiology, Biomarkers & Prevention. 22:2412-2415
- Publication Year :
- 2013
- Publisher :
- American Association for Cancer Research (AACR), 2013.
-
Abstract
- The unclear relationship of obesity to incident melanoma and nonmelanoma skin cancer (NMSC) risks was evaluated in the large, geographically diverse longitudinal, prospective Women's Health Initiative (WHI) observational study. Risks of melanoma and NMSC in normal weight women were compared with risks in overweight [body mass index (BMI) = 25–29.0 kg/m2] and obese (BMI ≥ 30 kg/m2) women, using Cox proportional hazards models for melanoma and logistic regression for NMSC. Over a mean 9.4 years of follow-up, there were 386 melanoma and 9,870 NSMC cases. Risk of melanoma did not differ across weight categories (P = 0.86), whereas in fully adjusted models, NMSC risk was lower in overweight [OR, 0.93; 95% confidence interval (CI), 0.89–0.99] and obese (OR, 0.85; 95% CI, 0.80–0.91) women (P < 0.001). Excess body weight was not associated with melanoma risk in postmenopausal women but was inversely associated with NMSC risk, possibly due to lower sun exposure in overweight and obese women. This supports previous work demonstrating the relationship between excess body weight and skin cancer risk. Cancer Epidemiol Biomarkers Prev; 22(12); 2412–5. ©2013 AACR.
- Subjects :
- medicine.medical_specialty
Skin Neoplasms
Epidemiology
Overweight
Article
Body Mass Index
Cohort Studies
Risk Factors
Internal medicine
medicine
Humans
Obesity
Melanoma
Aged
Gynecology
business.industry
Proportional hazards model
Women's Health Initiative
Age Factors
Cancer
Middle Aged
medicine.disease
United States
Logistic Models
Oncology
Women's Health
Female
Skin cancer
medicine.symptom
business
Body mass index
Cohort study
Subjects
Details
- ISSN :
- 15387755 and 10559965
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology, Biomarkers & Prevention
- Accession number :
- edsair.doi.dedup.....dfc853d7c5d5f0f93137b39197ae1b8e