Back to Search
Start Over
Population biological principles of drug-resistance evolution in infectious diseases
- Source :
- The Lancet Infectious Diseases
- Publication Year :
- 2011
-
Abstract
- The emergence of resistant pathogens in response to selection pressure by drugs and their possible disappearance when drug use is discontinued are evolutionary processes common to many pathogens. Population biological models have been used to study the dynamics of resistance in viruses, bacteria, and eukaryotic microparasites both at the level of the individual treated host and of the treated host population. Despite the existence of generic features that underlie such evolutionary dynamics, different conclusions have been reached about the key factors affecting the rate of resistance evolution and how to best use drugs to minimise the risk of generating high levels of resistance. Improved understanding of generic versus specific population biological aspects will help to translate results between different studies, and allow development of a more rational basis for sustainable drug use than exists at present.
- Subjects :
- Drug
media_common.quotation_subject
Population
Drug resistance
Computational biology
Biology
Bacterial genetics
03 medical and health sciences
Drug Resistance, Bacterial
Humans
Selection, Genetic
Evolutionary dynamics
education
030304 developmental biology
media_common
Antibacterial agent
0303 health sciences
education.field_of_study
Bacteria
Resistance (ecology)
030306 microbiology
business.industry
Biological Evolution
Anti-Bacterial Agents
Biotechnology
Infectious Diseases
business
Microparasite
Subjects
Details
- Language :
- English
- ISSN :
- 14733099
- Database :
- OpenAIRE
- Journal :
- The Lancet, Infectious diseases
- Accession number :
- edsair.doi.dedup.....dfc0fec510a7cdb0aaef91428cdfbac1
- Full Text :
- https://doi.org/10.1016/S1473-3099(10)70264-4