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Heart rate variability analysis allows early asphyxia detection in ovine fetus
- Source :
- Reproductive sciences (Thousand Oaks, Calif.). 16(5)
- Publication Year :
- 2009
-
Abstract
- Fetal heart rate (FHR) monitoring is commonly used to predict asphyxia but clinical and experimental studies have questioned its diagnostic value. We examined the usefulness of fetal heart rate variability (fHRV) measures in detecting early asphyxia using chronically instrumented fetal sheep under normoxic (n = 6) and asphyxic conditions (3 umbilical cord occlusions, n = 6). The occlusions consistently led to pH decreases from 7.35 ± 0.01 to 7.09 ± 0.03 (V < .05). FHR showed biphasic deceleration during each occlusion, associated with increasing arterial blood pressure (V < .05). RMSSD, an index of vagal modulation of fHRV, increased consistently during repeated occlusion induced FHR decelerations (V < .05). Under normoxic conditions, RMSSD did not change during FHR decelerations and decreased during FHR accelerations (V < .05). Our results suggest that an increase of RMSSD in association with FHR decelerations reflects initial vagal activation during fetal asphyxia. RMSSD may accurately identify asphyxic fetuses early. Clinical validation is needed.
- Subjects :
- Asphyxia
Fetus
Fetal Heart Rate Variability
business.industry
Obstetrics and Gynecology
Heart Rate, Fetal
Umbilical cord
medicine.anatomical_structure
Blood pressure
Early Diagnosis
Heart Rate
Pregnancy
Anesthesia
Prenatal Diagnosis
embryonic structures
Occlusion
Heart rate
medicine
Heart rate variability
Animals
Female
medicine.symptom
business
Sheep, Domestic
Subjects
Details
- ISSN :
- 19337205
- Volume :
- 16
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Reproductive sciences (Thousand Oaks, Calif.)
- Accession number :
- edsair.doi.dedup.....dfbd98d49bb7dbb60e5b347e71bb741c