Back to Search
Start Over
Role of homocysteine in the development and progression of Parkinson’s disease
- Source :
- Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2332-2338 (2020), Annals of Clinical and Translational Neurology
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson’s disease. Plasma homocysteine levels in patients with Parkinson’s disease are elevated compared to those of healthy individuals. High homocysteine drives PD development and progression while aggregating the clinical symptoms of PD patients. The relationship between PD and homocysteine involves multiple pathways, including nerve cell apoptosis, oxidative stress, and DNA damage. This is crucial for explaining how high homocysteine drives the PD procession. Elevated homocysteine level during PD development and progression offers a new strategy for the diagnosis and treatment of this disease.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Hyperhomocysteinemia
Parkinson's disease
Homocysteine
DNA damage
Apoptosis
Neurosciences. Biological psychiatry. Neuropsychiatry
Disease
Review
medicine.disease_cause
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Medicine
Humans
RC346-429
business.industry
General Neuroscience
Parkinson Disease
medicine.disease
030104 developmental biology
chemistry
Oxidative stress
Plasma homocysteine
Disease Progression
Parkinson’s disease
Neurology (clinical)
Neurology. Diseases of the nervous system
business
030217 neurology & neurosurgery
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 23289503
- Volume :
- 7
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Annals of Clinical and Translational Neurology
- Accession number :
- edsair.doi.dedup.....dfb43100c62b6f715dd8309410479530