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Effects of omeprazole on plasma levels of raltegravir

Authors :
Jeffery A. Chodakewitz
Charlotte M. Harvey
Marian Iwamoto
Hedy Teppler
H. Frank Farmer
Bo Jin
Neal Azrolan
Julie A. Stone
Rand R. Rhodes
Allison Moreau
Larissa Wenning
Sheila Breidinger
William D. Hanley
Bach-Yen Nguyen
John A. Wagner
Robin Isaacs
Source :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 48(4)
Publication Year :
2009

Abstract

Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with omeprazole coadministration in healthy subjects; this is likely secondary to an increase in bioavailability attributable to increased gastric pH. Increased gastric pH has been reported in HIV-1-infected individuals, and the effects of omeprazole in this intended population may be diminished. Further investigation is necessary.

Details

ISSN :
15376591
Volume :
48
Issue :
4
Database :
OpenAIRE
Journal :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Accession number :
edsair.doi.dedup.....dfa6d391d0a7628d9fb68170c77bfb94