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Effects of omeprazole on plasma levels of raltegravir
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 48(4)
- Publication Year :
- 2009
-
Abstract
- Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with omeprazole coadministration in healthy subjects; this is likely secondary to an increase in bioavailability attributable to increased gastric pH. Increased gastric pH has been reported in HIV-1-infected individuals, and the effects of omeprazole in this intended population may be diminished. Further investigation is necessary.
- Subjects :
- Microbiology (medical)
Adult
Male
Adolescent
Anti-HIV Agents
Population
Integrase inhibitor
HIV Infections
Pharmacology
Raltegravir Potassium
Plasma
Young Adult
Pharmacokinetics
Blood plasma
Medicine
Humans
Drug Interactions
education
Omeprazole
education.field_of_study
business.industry
Middle Aged
Raltegravir
Pyrrolidinones
Bioavailability
Infectious Diseases
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15376591
- Volume :
- 48
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....dfa6d391d0a7628d9fb68170c77bfb94