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Interleukin-17-Mediated Control of Parasitemia in Experimental Trypanosoma congolense Infection in Mice
- Source :
- Infection and Immunity. 78:5271-5279
- Publication Year :
- 2010
- Publisher :
- American Society for Microbiology, 2010.
-
Abstract
- BALB/c mice are highly susceptible to experimental Trypanosoma congolense infections, whereas C57BL/6 mice are relatively resistant. Infected highly susceptible BALB/c mice die of systemic inflammatory response syndrome. Because interleukin-17 (IL-17) and Th17 cells regulate inflammatory responses, we investigated their role in the pathogenesis of experimental African trypanosomiasis in mice. We show that the production of IL-17 by spleen and liver cells and the serum IL-17 level increased after T. congolense infection in mice. Interestingly, infected highly susceptible BALB/c mice produced more IL-17 and had more Th17 cells than infected relatively resistant C57BL/6 mice. Paradoxically, neutralization of IL-17 with anti-IL-17 monoclonal antibody in vivo induced higher parasitemia in both the susceptible and the relatively resistant mice. Interestingly, anti-IL-17 antibody-treated mice had higher serum levels of alanine aminotransferase and aspartate aminotransferase, and the production of IL-10 and nitric oxide by liver cells was markedly decreased. Moreover, recombinant IL-17-treated mice exhibited significantly faster parasite control and lower peak parasitemia compared to control mice. Collectively, these results suggest that the IL-17/Th17 axis plays a protective role in murine experimental African trypanosomiasis.
- Subjects :
- Trypanosoma congolense
medicine.drug_class
Ratón
medicine.medical_treatment
Immunology
Antibodies, Protozoan
Enzyme-Linked Immunosorbent Assay
Spleen
Parasitemia
Biology
Monoclonal antibody
Microbiology
Mice
Immunity
medicine
Animals
Mice, Inbred BALB C
Interleukin-17
Flow Cytometry
medicine.disease
Immunity, Innate
Mice, Inbred C57BL
Trypanosomiasis, African
Infectious Diseases
Cytokine
medicine.anatomical_structure
Female
Parasitology
Interleukin 17
Fungal and Parasitic Infections
Trypanosomiasis
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....df9db972d91858d545d145f41c178d09
- Full Text :
- https://doi.org/10.1128/iai.00168-10