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Interleukin-17-Mediated Control of Parasitemia in Experimental Trypanosoma congolense Infection in Mice

Authors :
Jude E. Uzonna
Shiby Kuriakose
Forough Khadem
Ping Jia
Zhirong Mou
Source :
Infection and Immunity. 78:5271-5279
Publication Year :
2010
Publisher :
American Society for Microbiology, 2010.

Abstract

BALB/c mice are highly susceptible to experimental Trypanosoma congolense infections, whereas C57BL/6 mice are relatively resistant. Infected highly susceptible BALB/c mice die of systemic inflammatory response syndrome. Because interleukin-17 (IL-17) and Th17 cells regulate inflammatory responses, we investigated their role in the pathogenesis of experimental African trypanosomiasis in mice. We show that the production of IL-17 by spleen and liver cells and the serum IL-17 level increased after T. congolense infection in mice. Interestingly, infected highly susceptible BALB/c mice produced more IL-17 and had more Th17 cells than infected relatively resistant C57BL/6 mice. Paradoxically, neutralization of IL-17 with anti-IL-17 monoclonal antibody in vivo induced higher parasitemia in both the susceptible and the relatively resistant mice. Interestingly, anti-IL-17 antibody-treated mice had higher serum levels of alanine aminotransferase and aspartate aminotransferase, and the production of IL-10 and nitric oxide by liver cells was markedly decreased. Moreover, recombinant IL-17-treated mice exhibited significantly faster parasite control and lower peak parasitemia compared to control mice. Collectively, these results suggest that the IL-17/Th17 axis plays a protective role in murine experimental African trypanosomiasis.

Details

ISSN :
10985522 and 00199567
Volume :
78
Database :
OpenAIRE
Journal :
Infection and Immunity
Accession number :
edsair.doi.dedup.....df9db972d91858d545d145f41c178d09
Full Text :
https://doi.org/10.1128/iai.00168-10