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Isolation of 2,5-diketopiperazines from Lysobacter capsici AZ78 with activity against Rhodococcus fascians
- Source :
- Natural Product Research. 35:4969-4977
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Inhibitory activity of the biocontrol bacterial strain Lysobacter capsici AZ78 is related to the production of cyclo(l-Pro-l-Tyr), a 2,5-diketopiperazine with in vitro and in vivo toxic activity against Phytophthora infestans and Plasmopara viticola. Further investigation of culture filtrate organic extracts showed its ability to produce other 2,5-diketopiperazines. They were isolated and identified by spectroscopic (1H NMR and ESIMS) and physic (specific optical rotation) methods as cyclo(l-Pro-l-Val), cyclo(d-Pro-d-Phe), cyclo(l-Pro-l-Leu), and cyclo(d-Pro-l-Tyr). When tested against the phytopathogenic Gram-positive bacterium Rhodococcus fascians LMG 3605, cyclo(l-Pro-l-Val) showed a toxic activity similar to chloramphenicol at a comparable concentration. Overall, these data suggest that 2,5-diketopiperazines represent a class of metabolites characterizing the metabolome of L. capsici AZ78. Furthermore, the toxic activity showed by cyclo(l-Pro-l-Val) against R. fascians LMG 3605 broaden the spectrum activity of 2,5-diketopiperazines against phytopathogenic microorganisms enforcing their potential development as biopesticides.
- Subjects :
- Biopesticides
Lysobacter capsici
cyclic dipeptide
Plant Science
Rhodococcus fascians
01 natural sciences
Biochemistry
Analytical Chemistry
Microbiology
Cyclic dipeptides
In vivo
Diketopiperazines
25-diketopiperazine
25-diketopiperazines
biology
010405 organic chemistry
Chemistry
Organic Chemistry
food and beverages
biology.organism_classification
Isolation (microbiology)
biopesticide
Bacterial strain
In vitro
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Biopesticide
lipids (amino acids, peptides, and proteins)
Settore AGR/12 - PATOLOGIA VEGETALE
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi.dedup.....df982b2c33b6cef4dcb2145884b58b90