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Modified DCF (mDCF) regimen seems to be as effective as original DCF in advanced gastric cancer (AGC)
- Source :
- Clinical and Translational Oncology. 15:403-408
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- The aim of this retrospective study (from January 2007 to December 2011) was to investigate the efficacy and tolerability of mDCF schedule for chemotherapy-naïve AGC patients.Patients (n = 54) with locally inoperable or distant metastasis and performance status of 0-2 were eligible. The triplet combination chemotherapy consisting of docetaxel 60 mg/m(2) on day 1, cisplatin 60 mg/m(2) on day 1, and 5-fluorouracil 600 mg/m(2) for 5 days of continuous infusion were administered every 21 days, up to nine cycles. Prophylactic G-CSF was not allowed.In all, 36 (67 %) patients were male and 18 (33 %) were female; median age was 59 years. The majority of patients (n = 46, 85 %) had metastatic disease and 8 (15 %) of them had locally advanced disease. Liver metastasis and peritonitis carcinomatosa were found in 20 (43 %) and 18 (39 %) of the 46 cases, respectively. The median cycle of chemotherapy was 6. In assessing 50 patients for response evaluation, one had complete response. Partial response was achieved in 27 (54 %) patients. Seventeen patients (34 %) had stable disease and 5 (10 %) had progressive disease, while 4 % (n = 2) and 11 % (n = 6) of the patients developed severe (grade 3-4) neutropenia and anemia, respectively. During the median follow-up time (6.9 months, range 0.4-24), 28 (52 %) patients died. The overall and progression-free survival were 10.7 [95 % CI 8.9-12.4] and 6.8 [95 % CI 5.8-7.8] months, respectively.Although this was not a prospective comparative study, the mDCF regimen seems to be as effective as the original DCF in AGC with acceptable and manageable side effects.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Docetaxel
Stomach Neoplasms
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Neoplasm Metastasis
Aged
Aged, 80 and over
business.industry
Retrospective cohort study
General Medicine
Middle Aged
Advanced gastric cancer
humanities
Surgery
body regions
stomatognathic diseases
Regimen
Tolerability
Female
Taxoids
Fluorouracil
Cisplatin
business
medicine.drug
Subjects
Details
- ISSN :
- 16993055 and 1699048X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Oncology
- Accession number :
- edsair.doi.dedup.....df94a6b4f83b8decda5cbe9f4d69a856