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Involvement of N-Methyl-D-Aspartic Acid Receptor and DL-α-Amino-3-Hydroxy-5- Methyl-4-Isoxazole Propionic Acid Receptor in Ginsenosides Rb1 and Rb3 against Oxygen-Glucose Deprivation-Induced Injury in Hippocampal Slices from Rat
- Source :
- Pharmacology. 101(3-4)
- Publication Year :
- 2017
-
Abstract
- Objective: Ginsenosides, Rb1 and Rb3, are the major protopanaxadiol components of ginseng saponin. In the present study, the influences of ginsenosides Rb1 and Rb3 on N-methyl-D-aspartic acid (NMDA) receptor or DL-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated synaptic transmission after oxygen-glucose deprivation (OGD) were investigated. Methods: NMDA receptor population spike (NMDA-PS) or AMPA receptor-mediated population spike (AMPA-PS) was recorded in the CA1 pyramidal cell layer of rat hippocampal slices by electrophysiological techniques. Results: Under normal conditions, ginsenosides Rb3 and Rb1 depressed glutamate receptors-mediated synaptic transmission. Fourteen min of OGD resulted in a poor recovery amplitude of NMDA-PS or AMPA-PS after reoxygenation. Ginsenoside Rb3 significantly delayed the appearance of transient recovery of PS during OGD, and improved the recovery amplitudes of NMDA-PS and AMPA-PS after reoxygenation. However, the similar protective effects of ginsenoside Rb1 were observed only on NMDA-PS but not AMPA-PS. Conclusion: These results suggest that ginsenosides Rb1 and Rb3 have the different inhibitions on NMDA and AMPA receptors-mediated response, which may partially explain the different protective effects of these agents on ischemic neuronal death.
- Subjects :
- 0301 basic medicine
Male
Ginsenosides
N-Methyl-D-aspartic acid
AMPA receptor
Pharmacology
Hippocampus
Receptors, N-Methyl-D-Aspartate
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
Ginseng
0302 clinical medicine
Animals
Receptors, AMPA
Hypoxia
Glutamate receptor
Population spike
General Medicine
Oxygen
030104 developmental biology
Glucose
nervous system
chemistry
Ginsenoside
Protopanaxadiol
NMDA receptor
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14230313
- Volume :
- 101
- Issue :
- 3-4
- Database :
- OpenAIRE
- Journal :
- Pharmacology
- Accession number :
- edsair.doi.dedup.....df90a93edb6e809ca0135258b8ba0b72