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RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
- Source :
- Nature genetics. 32(4)
- Publication Year :
- 2002
-
Abstract
- RNASEL (encoding ribonuclease L) has recently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene. We determined that the RNASEL variant Arg462Gln has three times less enzymatic activity than the wildtype and is significantly associated with prostate cancer risk (P = 0.007). At least one copy of the mutated allele that causes this substitution is carried by nearly 60% of the men in our study. Men that are heterozygous with respect to the mutated allele have 50% greater risk of prostate cancer than non-carriers, and homozygotes have more than double the risk.
- Subjects :
- Male
Heterozygote
DNA Mutational Analysis
Gene Dosage
Arginine
Xenotropic murine leukemia virus-related virus
MSR1
Prostate cancer
Prostate
Endoribonucleases
Genetics
medicine
Humans
Point Mutation
Genetic Predisposition to Disease
Allele
Germ-Line Mutation
Aged
biology
Homozygote
Wild type
RNASEL Gene
Prostatic Neoplasms
Middle Aged
Prostate-Specific Antigen
medicine.disease
biology.organism_classification
Pedigree
medicine.anatomical_structure
Amino Acid Substitution
Case-Control Studies
Cancer research
biology.protein
Ribonuclease L
Gene Deletion
Subjects
Details
- ISSN :
- 10614036
- Volume :
- 32
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.doi.dedup.....df8e48c6eb2898396e6ef15468d915c3