Back to Search
Start Over
Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies
- Source :
- BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019), BMC Infectious Diseases
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background Tuberculosis and diabetes mellitus are significant global public health challenges. In Sub-Saharan Africa, study findings regarding prevalence of diabetes mellitus amongst tuberculosis patients have been inconsistent and highly variable. Therefore, this systematic review and meta-analysis estimates the overall prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa. Methods Four international databases (PubMed, Google Scholar, Science Direct and Cochrane Library) were systematically searched. We included all observational studies reporting the prevalence of DM among TB patients in Sub-Saharan Africa. All necessary data for this review were extracted using a standardized data extraction format by two authors (CT and AA1). STATA Version 14 statistical software was employed to conduct meta-analysis. The Cochrane Q test statistics and I2 test were used to assess the heterogeneity of the studies. Finally, a random effects meta-analysis model was computed to estimate the pooled prevalence of diabetes mellitus in TB patients. Besides, subgroup analysis was done based on different factors. Results In the meta-analysis, sixteen studies fulfilled the inclusion criteria and were included. The findings of these 16 studies revealed that the pooled prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was 9.0% (95% CI: 6.0, 12.0%). The highest prevalence of diabetes mellitus among tuberculosis patients was found in Nigeria (15%), followed by Tanzania (11%), and then Ethiopia (10%). Besides, the prevalence of diabetes mellitus among HIV infected TB patients was (8.9%) which is slightly higher than HIV uninfected (7.7%) TB patients. Conclusion Diabetes mellitus among tuberculosis patients in Sub-Saharan Africa was significantly high. Moreover, this study found that there was a high prevalence of DM among HIV infected than uninfected TB patients. It is strongly recommended to screen for DM among TB patients and special emphasis should be given for early screening of DM among TB/HIV co-infected patients. Electronic supplementary material The online version of this article (10.1186/s12879-019-3892-8) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Tuberculosis
030106 microbiology
Subgroup analysis
Type 2 diabetes
Cochrane Library
Type1/type 2 diabetes mellitus
lcsh:Infectious and parasitic diseases
Diabetes Complications
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
medicine
Prevalence
Humans
lcsh:RC109-216
030212 general & internal medicine
Africa South of the Sahara
Sub-Saharan Africa
business.industry
Incidence (epidemiology)
medicine.disease
Observational Studies as Topic
Infectious Diseases
Systematic review
Meta-analysis
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....df79934e71b68c36f79eb06a569b325b