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Interaction of prenatal bisphenols, maternal nutrients, and toxic metal exposures on neurodevelopment of 2-year-olds in the APrON cohort
- Source :
- Environment International, Vol 155, Iss, Pp 106601-(2021)
- Publication Year :
- 2021
-
Abstract
- Background: Epidemiological studies suggest that Bisphenol-A (BPA) is a developmental neurotoxicant, but the modifying effects of maternal nutrient status or neurotoxicant metal co-exposures have not been reported. Bisphenol-S (BPS) is being used as a BPA-alternative, but few epidemiological studies have evaluated its effects. Objectives: To examine if prenatal maternal BPA or BPS exposure are associated with children’s neurodevelopment at two years of age while adjusting for effect-measure modification by sex, maternal nutrients, and co-exposure to neurotoxic metals. Methods: Total BPA and BPS concentrations were analyzed in spot maternal urine from the second trimester; metals and maternal nutrient status were analyzed in blood. Child neurodevelopment was evaluated with the Bayley Scales of Infant Development-III (Bayley-III) at age 2 (394 maternal-child pairs) and linear regression was used to investigate associations. Results: Among nutrients and neurotoxic metals, selenium (Se) and cadmium (Cd) were the most significant predictors of Bayley-III scale scores. Higher maternal Cd was significantly correlated with poorer motor performance (p
- Subjects :
- Male
medicine.medical_specialty
endocrine system
010504 meteorology & atmospheric sciences
Bisphenol
Bisphenol S
Neurodevelopment
Physiology
010501 environmental sciences
01 natural sciences
Bayley Scales of Infant Development
Cohort Studies
Nutrient
Bisphenol A
Child Development
Pregnancy
Epidemiology
Medicine
Humans
GE1-350
Benzhydryl Compounds
Adverse effect
0105 earth and related environmental sciences
General Environmental Science
Maternal urine
business.industry
urogenital system
Infant
Nutrients
Vitamins
Child development
Maternal nutrients
Environmental sciences
Heavy metals
Child, Preschool
Prenatal Exposure Delayed Effects
Cohort
Female
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 18736750
- Volume :
- 155
- Database :
- OpenAIRE
- Journal :
- Environment international
- Accession number :
- edsair.doi.dedup.....df7960a2497272f4f0c64dd5f5edf9b0