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Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes
- Source :
- FEBS Letters. 583:3718-3724
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Galectin-3 plays a role in atherosclerotic diseases, and the effect of adiponectin that protects from atherosclerotic diseases on monocytic galectin-3 was analysed. Adiponectin reduced galectin-3 mRNA, its cellular and soluble form, and this effect was impaired in T2D cells. Cellular galectin-3 was higher in monocytes of overweight than normal-weight donors and was highest in T2D cells. Cellular galectin-3 positively correlated with the BMI of the donors and negatively with soluble monocyte galectin-3. Circulating levels of total adiponectin did not correlate with cellular or soluble galectin-3 indicating that additional factors contribute to higher cellular monocytic galectin-3 in obesity and T2D.
- Subjects :
- Male
Time Factors
Galectin 3
Palmitic Acid
Type 2 diabetes
Monocyte
Biochemistry
Monocytes
Body Mass Index
chemistry.chemical_compound
Structural Biology
Galectin-3
Cells, Cultured
Aged, 80 and over
Reverse Transcriptase Polymerase Chain Reaction
Chemistry
Middle Aged
Metformin
Cholesterol
medicine.anatomical_structure
Adiponectin
medicine.drug
Adult
medicine.medical_specialty
animal structures
Immunoblotting
Biophysics
Enzyme-Linked Immunosorbent Assay
Internal medicine
Type 2 diabetes mellitus
otorhinolaryngologic diseases
Genetics
medicine
Humans
Obesity
Molecular Biology
Aged
Messenger RNA
Dose-Response Relationship, Drug
nutritional and metabolic diseases
Cell Biology
Ribonucleotides
Aminoimidazole Carboxamide
medicine.disease
stomatognathic diseases
Pyrimidines
Endocrinology
Diabetes Mellitus, Type 2
Solubility
Pyrazoles
Oleic Acid
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 583
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....df76c001bbee9ba23ff44632bc11e64a