Long-term follow-up of endothelial cell change after artisan phakic intraocular lens implantation

Objective: To report endothelial cell densities (ECDs) and their correlation to anterior chamber depth (ACD) after implantation of the Artisan intraocular phakic lens. Design: Prospective observational case series. Participants: Three hundred eighteen eyes of 173 myopic patients treated with the Artisan iris-fixated phakic intraocular lens (IOL). Methods: Eyes with an ACD ranging between 2.89 and 4.5 mm were implanted with the Artisan phakic IOL. Endothelial cell density measurements were performed preoperatively and at each follow-up examination using a noncontact specular microscope. Main Outcome Measures: Endothelial cell density (cells per square millimeter). Results: Follow-up ranged between 1 (82 eyes) and 7 years (13 eyes) (mean, 35.3-20.7 [standard deviation] months per eye). After 3 years, there was a significant loss in ECD (P