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The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory
- Source :
- Current Pharmaceutical Design
- Publication Year :
- 2016
- Publisher :
- Bentham Science Publishers Ltd., 2016.
-
Abstract
- The endocannabinoid system (ECS) is a group of neuromodulatory lipids and their receptors, which are widely distributed in mammalian tissues. ECS regulates various cardiovascular, nervous, and immune system functions inside cells. In recent years, there has been a growing body of evidence for the use of synthetic and natural cannabinoids as potential anticancer agents. For instance, the CB1 and CB2 receptors are assumed to play an important role inside the endocannabinoid system. These receptors are abundantly expressed in the brain and fatty tissue of the human body. Despite recent developments in molecular biology, there is still a lack of knowledge about the distribution of CB1 and CB2 receptors in the human kidney and their role in kidney cancer. To address this gap, we explore and demonstrate the role of the endocannabinoid system in renal cell carcinoma (RCC). In this brief overview, we elucidate the therapeutic aspects of the endocannabinoid system for various cancers and explain how this system can be used for treating kidney cancer. Overall, this review provides new insights into cannabinoids' mechanisms of action in both in vivo and in vitro models, and focuses on recent discoveries in the field.
- Subjects :
- 0301 basic medicine
Cannabinoid receptor
Endocannabinoid system
Pharmacology
Biology
Article
03 medical and health sciences
0302 clinical medicine
Immune system
Drug Discovery
CB1 and CB2 receptors
medicine
Cannabinoid receptor type 2
Humans
Lack of knowledge
Receptor
Carcinoma, Renal Cell
cannabinoids
endocannabinoid system
renal cell carcinoma
Biological Products
Molecular Structure
Cannabinoids
Cancer
medicine.disease
Antineoplastic Agents, Phytogenic
Renal cell carcinoma
Kidney Neoplasms
030104 developmental biology
030220 oncology & carcinogenesis
lipids (amino acids, peptides, and proteins)
Drug Screening Assays, Antitumor
Kidney cancer
Neuroscience
Endocannabinoids
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....df610e57b4b0efc8ee9282259c3dd482