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GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)
- Source :
- International journal of oncology. 56(4)
- Publication Year :
- 2019
-
Abstract
- Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene that plays an important regulatory role in detoxification, anti‑oxidative damage, and the occurrence of various diseases. The aim of the present study was to review the association between the expression of GSTP1 and the development and treatment of various cancers, and discuss GSTP1 methylation in several malignant tumors, such as prostate, breast and lung cancer, as well as hepatocellular carcinoma; to review the association between polymorphism of the GSTP1 gene and various diseases; and to review the effects of GSTP1 on electrophilic oxidative stress, cell signal transduction, and the regulation of carcinogenic factors. Collectively, GSTP1 plays a major role in the development of various diseases.
- Subjects :
- 0301 basic medicine
Cancer Research
GSTP1 Gene
Biology
urologic and male genital diseases
Polymorphism, Single Nucleotide
03 medical and health sciences
GSTP1
0302 clinical medicine
Neoplasms
Animals
Humans
Promoter Regions, Genetic
neoplasms
Regulation of gene expression
Oncogene
Methylation
DNA Methylation
Gene Expression Regulation, Neoplastic
030104 developmental biology
Oncology
Glutathione S-Transferase pi
030220 oncology & carcinogenesis
DNA methylation
Cancer research
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 17912423
- Volume :
- 56
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International journal of oncology
- Accession number :
- edsair.doi.dedup.....df59b49c6ed04b4f265ed42a879dff01