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Comparative effects of losartan, captopril, and enalapril on murine acute myocarditis due to encephalomyocarditis virus
- Source :
- Journal of cardiovascular pharmacology. 26(1)
- Publication Year :
- 1995
-
Abstract
- Losartan, a recently developed nonpeptide angiotensin II (AII) receptor antagonist, was orally administered for 14 days to mice with viral myocarditis, beginning 7 days after encephalomyocarditis virus inoculation. The angiotensin-converting enzyme inhibitors (ACEI) captopril and enalapril were also administered in the same manner to compare the therapeutic effects of these three drugs on the degree of myocarditis, acute heart failure, and left ventricular (LV) hypertrophy. Heart weight and the heart weight/body weight ratio were reduced by losartan (60 mg/kg/day) and captopril (7.5 mg/kg/day), but not by enalapril (1 mg/kg/day). LV wall thickness and cavity dimension were decreased in the losartan and captopril groups. Captopril reduced both myocardial necrosis and inflammation, whereas enalapril reduced myocardial necrosis but not inflammation. However, none of the studied losartan doses (1.2, 12, 60 mg/kg/day) influenced myocardial necrosis and inflammation resulting from viral infection. Thus, specific blockade of AII is beneficial in congestive heart failure (CHF) and LV hypertrophy but is not effective in viral-evoked inflammation and injury.
- Subjects :
- medicine.medical_specialty
Myocarditis
Viral Myocarditis
Captopril
Heart disease
Administration, Oral
Tetrazoles
Angiotensin-Converting Enzyme Inhibitors
Losartan
Mice
Random Allocation
Enalapril
Internal medicine
medicine
Cardiovirus Infections
Animals
cardiovascular diseases
Encephalomyocarditis virus
Antihypertensive Agents
Pharmacology
Heart Failure
Mice, Inbred C3H
business.industry
Myocardium
Biphenyl Compounds
Body Weight
Imidazoles
Heart
Organ Size
medicine.disease
Angiotensin II
Endocrinology
Therapeutic Equivalency
Heart failure
Acute Disease
Female
Hypertrophy, Left Ventricular
Cardiology and Cardiovascular Medicine
business
hormones, hormone substitutes, and hormone antagonists
Injections, Intraperitoneal
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 26
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular pharmacology
- Accession number :
- edsair.doi.dedup.....df5900bf16cf395e1be3a43e3816d0da