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Progressive multifocal leukoencephalopathy in HIV-1-infected children
- Source :
- AIDS (London, England). 6(8)
- Publication Year :
- 1992
-
Abstract
- OBJECTIVE To describe the clinical and pathologic features of two HIV-1-infected children with progressive multifocal leukoencephalopathy (PML). DESIGN Case report. SETTING University-affiliated, public-health trust hospital. METHODS Two HIV-1-infected children with PML are described. A 13-year-old girl, presumed to be congenitally infected with HIV-1, presented with dysarthria and paresthesias of the tongue and chin that evolved rapidly to dementia, muteness and severe spastic quadriparesis. The other patient, a 10-year-old boy who developed HIV-1 infection from a blood transfusion at the age of 3 years, presented with a facial palsy with subsequent development of right hemiparesis and aphasia. RESULTS Brain biopsy in the first child and autopsy in the second confirmed the diagnosis of PML. In both patients, the CD4 T-lymphocyte count was less than 100 x 10(6)l at the time of neurological presentation. CONCLUSION Despite seroepidemiological studies suggesting that the majority of individuals are infected with JC virus during childhood, PML is rare in children with impaired cell-mediated immunity. Our patients illustrate that PML is among the neurological complications of HIV-1 infection in children.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Pathology
Adolescent
Immunology
JC virus
Autopsy
HIV Infections
medicine.disease_cause
Dysarthria
Aphasia
Immunology and Allergy
Medicine
Dementia
Humans
Child
Palsy
medicine.diagnostic_test
business.industry
Brain biopsy
Progressive multifocal leukoencephalopathy
Leukoencephalopathy, Progressive Multifocal
virus diseases
Brain
medicine.disease
Infectious Diseases
HIV-1
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 6
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- AIDS (London, England)
- Accession number :
- edsair.doi.dedup.....df53099e133480f5b7370d6c891018d5