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Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections
- Source :
- Microbes and Infection. 21:336-340
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from N. meningitidis serogroup B were detected. Thus, the cross-reactive protection against meningococcal and pneumococcal infections has been demonstrated in vivo. Presumably it indicates the presence of common epitopes in the N. meningitidis IgA1 protease and S. pneumoniae surface proteins.
- Subjects :
- 0301 basic medicine
Cross Protection
030106 microbiology
Immunology
Meningococcal Vaccines
chemical and pharmacologic phenomena
Meningococcal vaccine
Neisseria meningitidis
medicine.disease_cause
Microbiology
Pneumococcal Infections
Epitope
03 medical and health sciences
fluids and secretions
stomatognathic system
Streptococcus pneumoniae
medicine
Animals
Mice, Inbred BALB C
Vaccines, Synthetic
biology
Streptococcus
Immune Sera
Serine Endopeptidases
medicine.disease
Antibodies, Bacterial
Recombinant Proteins
Meningococcal Infections
Pneumococcal infections
030104 developmental biology
Infectious Diseases
Immunization
biology.protein
Female
Rabbits
Antibody
Subjects
Details
- ISSN :
- 12864579
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Microbes and Infection
- Accession number :
- edsair.doi.dedup.....df4f32a070477266af6131c3f3549f4f