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Early vascular response of ultra-thin bioresorbable polymer sirolimus-eluting stents assessed by optical frequency domain imaging: the EVALUATION study
- Source :
- Cardiovascular Intervention and Therapeutics. 36:281-288
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- This study aimed to evaluate the early vascular response of ultra-thin strut bioresorbable polymer sirolimus-eluting stents (BP SES) using optical frequency domain imaging (OFDI). Ultra-thin strut BP SES have superior outcomes in terms of efficacy and safety endpoints when compared to other thin strut new-generation stents. However, the factors contributing to the superiority of BP SES over other thin strut new-generation stents are unclear. A total of 32 patients with multivessel disease requiring staged procedures at 1 month were enrolled from 3 cardiovascular institutions; of these, 31 were immediately assessed by OFDI (n = 31). All patients were assessed at 1 month after ultra-thin strut BP SES implantation. The primary endpoint was % of uncovered struts. A total of 1723 cross sections (17,014 struts) were analyzed at baseline and 1 month after percutaneous coronary intervention. The % uncovered struts at 1-month follow-up was 7.7% (4.0, 13.8). Furthermore, the covered strut % (88.4% and 80.4%, P = 0.013) and malapposition rate (2.7% and 4.3%, P = 0.012) were significantly different between the 60-μm and 80-μm stents. Ultra-thin strut BP SES implantation may feasibly achieve early vascular responses due to the ultra-thin struts. This may ultimately lead to lower stent thrombosis and target lesion failure rates. Clinical trial registration University Hospital Medical Information Network Clinical Trials Registry (No. UMIN000033406).
- Subjects :
- Male
Target lesion
medicine.medical_specialty
Time Factors
Polymers
medicine.medical_treatment
Bioresorbable polymers
Coronary Artery Disease
030204 cardiovascular system & hematology
Prosthesis Design
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Absorbable Implants
medicine
Clinical endpoint
Humans
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
030212 general & internal medicine
Lead (electronics)
Aged
Aged, 80 and over
Sirolimus
medicine.diagnostic_test
business.industry
Percutaneous coronary intervention
Drug-Eluting Stents
Interventional radiology
General Medicine
equipment and supplies
Clinical trial
Treatment Outcome
surgical procedures, operative
cardiovascular system
Female
Radiology
Cardiology and Cardiovascular Medicine
business
Immunosuppressive Agents
Tomography, Optical Coherence
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 18684297 and 18684300
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Intervention and Therapeutics
- Accession number :
- edsair.doi.dedup.....df4bb1f7622aaf12e4ea877cab375918