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Prevention of anemia in patients with solid tumors receiving platinum-based chemotherapy by recombinant human erythropoietin (rHuEPO): A prospective, open label, randomized trial by the hellenic cooperative oncology group
- Source :
- Oncology
- Publication Year :
- 2003
-
Abstract
- Objectives: Platinum compounds are commonly associated with significant anemia. Erythropoietin administration has been found effective in correcting anemia in patients with solid tumors receiving chemotherapy. We conducted a randomized, open label study to assess the efficacy of erythropoietin in preventing transfusions and significant anemia (hemoglobin Methods: One hundred forty-four patients with hemoglobin Results: All patients were evaluable for efficacy. Transfusions were reduced by the administration of rHuEPO (15.3 vs. 33.3%, p = 0.019), and fewer patients developed significant anemia (16.6 vs. 45.8%, p < 0.0001). Subgroup analysis showed that patients with observed to predicted (O/P) serum erythropoietin levels ≤0.9 and responders to chemotherapy benefited from erythropoietin administration in contrast to patients with O/P >0.9 or non-responders. Conclusions: rHuEPO at a dose of 10,000 U thrice weekly prevents transfusions and development of significant anemia in patients with solid tumors receiving platinum-based chemotherapy.
- Subjects :
- Oncology
Male
Cancer Research
Organoplatinum Compounds
endocrine system diseases
Organoplatinum Compounds/administration & dosage/*adverse effects
medicine.medical_treatment
Intestine obstruction
law.invention
Randomized controlled trial
Risk Factors
law
hemic and lymphatic diseases
Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Solid tumors
80 and over
Medicine
Pericarditis
Prospective Studies
Treatment outcome
Erythropoietin/administration & dosage/*therapeutic use
Middle aged
Organoplatinum compounds
Priority journal
Aged, 80 and over
Anemia, Hypochromic
Recombinant
Greece
Solid tumor
Blood transfusion
Anemia
General Medicine
Middle Aged
Prognosis
Recombinant Proteins
humanities
Anemia, Hypochromic/chemically induced/*prevention & control
Treatment Outcome
Hypertension
Recombinant DNA
Female
Cancer chemotherapy
Infection
medicine.drug
Human
Adult
Diarrhea
Quality of life
medicine.medical_specialty
Hypochromic
Neutropenia
Fever
Vomiting
Febrile neutropenia
Major clinical study
Side effect
Article
Internal medicine
Antineoplastic combined chemotherapy protocols
Humans
Blood Transfusion
In patient
effects
Recombinant erythropoietin
Erythropoietin
Aged
Platinum
Chemotherapy
business.industry
Bleeding
medicine.disease
Antineoplastic Combined Chemotherapy Protocols/administration & dosage/*adverse
Neoplasms/*drug therapy
Platinum chemotherapy
Drug effect
Drug efficacy
Risk factors
Quality of Life
Hypercalcemia
Platinum Compound
Cancer patient
Heart infarction
business
Complication
Controlled study
Prospective studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Oncology
- Accession number :
- edsair.doi.dedup.....df47828db92569e03b19ea0169d5d004